miR-155–5p predictive role to decelerate foam cell atherosclerosis through CD36, VAV3, and SOCS1 pathway

MicroRNAs (miRNAs) are noncoding RNA molecules that play a significant role in atherosclerosis pathogenesis through post-transcriptional regulation. In the present work, bioinformatic analysis using TargetScan and miRdB databases was performed to identify miRNAs targeting three genes involved foam cell (CD36, Vav3, SOCS1). A total number of hundred sixty-seven were recognized only miR-155–5p selected for further evaluation based on Venn analysis. Another objective this study evaluate biological process regulatory network associated with DIANA, DAVID, Cytoscape, STRING tools. Additionally, comprehensive literature review prove function atherosclerosis. might be related ox-LDL uptake endocytosis macrophage by CD36 Vav3 which showed from KEGG pathways hsa04979, hsa04666, hsa04145 H, hsa04810, GO:0099632, GO:0060100, GO:0010743, GO:001745. Furthermore, also predicted increase cholesterol efflux inhibit SOCS1 expression pathway hsa04120. Eleven original studies included strongly suggest inhibition.